Expression of Nedd9 in Transbronchial Biopsies of Lung Adenocarcinoma.

Abstract

Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium. The majority of cases are diagnosed in advanced stage (i.e. stages IIIB and IV), often with scanty amount of tissue in transbronchial biopsies or cytology specimens. The aim of the present study was to investigate the expression of the scaffolding protein neural precursor cell expressed, developmentally downregulated 9 (NEDD9) in small biopsies of lung adenocarcinoma. The expression of NEDD9 was analyzed immunohistochemically in 71 formalin-fixed and paraffin-embedded transbronchial biopsy specimens of primary lung adenocarcinoma. Nuclear and cytoplasmic NEDD9 expression was detected indicating activation of the epithelial-mesenchymal transition process. Direct relationship between the expression of NEDD9 and survival was not demonstrated.

• Authors: Jelena Ostojić, Luka Brčić, Pero Hrabač, Sven Seiwerth
• Journal: Acta clinica Croatica (Acta Clin Croat) Vol. 57 Issue 2 Pg. 251-256 (Jun 2018) ISSN: 0353-9466 [Print] Croatia
• PMID: 30431717 (Publication Type: Journal Article)

Chemical References

• Adaptor Proteins, Signal Transducing
• Biomarkers, Tumor
• NEDD9 protein, human
• Phosphoproteins

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• Adenocarcinoma
• Adenocarcinoma of Lung (diagnosis, metabolism)
• Biomarkers, Tumor (metabolism)
• Biopsy
• Humans
• Lung Neoplasms (diagnosis, metabolism)
• Phosphoproteins (metabolism)