Patients' experience of screening CT colonography with reduced and full bowel preparation in a randomised trial.

Abstract

OBJECTIVES:

To assess patients' experience of bowel preparation and procedure for screening CT colonography with reduced (r-CTC) and full cathartic preparation (f-CTC) that showed similar detection rate for advanced neoplasia in a randomised trial.

METHODS:

Six hundred seventy-four subjects undergoing r-CTC and 612 undergoing f-CTC in the SAVE trial were asked to complete two pre-examination questionnaires-(1) Life Orientation Test - Revised (LOT-R) assessing optimism and (2) bowel preparation questionnaire-and a post-examination questionnaire evaluating overall experience of CTC screening test. Items were analysed with chi-square and t test separately and pooled.

RESULTS:

LOT-R was completed by 529 (78%) of r-CTC and by 462 (75%) of f-CTC participants and bowel preparation questionnaire by 531 (79%) subjects in the r-CTC group and by 465 (76%) in the f-CTC group. Post-examination questionnaire was completed by 525 (78%) subjects in the r-CTC group and by 453 (74%) in the f-CTC group. LOT-R average score was not different between r-CTC (14.27 ± 3.66) and f-CTC (14.54 ± 3.35) (p = 0.22). In bowel preparation questionnaire, 88% of r-CTC subjects reported no preparation-related symptoms as compared to 70% of f-CTC subjects (p < 0.001). No interference of bowel preparation with daily activities was reported in 80% of subjects in the r-CTC group as compared to 53% of subjects in the f-CTC group (p < 0.001). In post-examination questionnaire, average scores for discomfort of the procedure were not significantly different between r-CTC (3.53 ± 0.04) and f-CTC (3.59 ± 0.04) groups (p = 0.84).

CONCLUSIONS:

Reduced bowel preparation is better tolerated than full preparation for screening CT colonography.

KEY POINTS:

• Reduced bowel preparation is better tolerated than full preparation for screening CT colonography. • Procedure-related discomfort of screening CT colonography is not influenced by bowel preparation. • Males tolerate bowel preparation and CT colonography screening procedure better than females.

• Authors: Lapo Sali, Leonardo Ventura, Grazia Grazzini, Alessandra Borgheresi, Silvia Delsanto, Massimo Falchini, Beatrice Mallardi, Paola Mantellini, Stefano Milani, Stefano Pallanti, Marco Zappa, Mario Mascalchi
• Journal: European radiology (Eur Radiol) Vol. 29 Issue 5 Pg. 2457-2464 (May 2019) ISSN: 1432-1084 [Electronic] Germany
• PMID: 30402705 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Cathartics

Topics

• Cathartics (administration & dosage)
• Colonography, Computed Tomographic (methods)
• Colorectal Neoplasms (diagnosis)
• Early Detection of Cancer (methods)
• Female
• Humans
• Male
• Mass Screening (methods)
• Middle Aged
• Patient Satisfaction
• Reproducibility of Results
• Surveys and Questionnaires