A benzodiazepine receptor inverse agonist inhibits stress-induced ulcer formation.

Abstract

The effects of a benzodiazepine receptor inverse agonist (FG 7142) on gastric ulcer formation were studied in restrained rats. FG 7142 (10-50 mg/kg) reduced in a dose-dependent fashion both the number and cumulative length of gastric ulcers elicited by restraint for 2 hr at 4 degrees C, but did not affect ulcer formation in unrestrained animals maintained in this environment. FG 7142 also reduced gastric ulcer formation in restrained rats maintained at 22 degrees C for 5 hr. The ability of FG 7142 to reduce restraint-stress induced gastric ulcer formation was blocked by the benzodiazepine receptor antagonist ZK 93426 and the beta-adrenoceptor antagonist propranolol. These findings suggest that FG 7142 produces a benzodiazepine-receptor mediated reduction in gastric ulcer formation, which may result from its ability to increase activity of the sympathetic nervous system.

• Authors: R Trullas, H Ginter, P Skolnick
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 27 Issue 1 Pg. 35-9 (May 1987) ISSN: 0091-3057 [Print] United States
• PMID: 3039540 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbolines
• Receptors, GABA-A
• FG 7142
• Chlordiazepoxide
• ZK 93426
• Propranolol

Topics

• Animals
• Carbolines (pharmacology)
• Chlordiazepoxide (pharmacology)
• Male
• Propranolol (pharmacology)
• Rats
• Rats, Inbred Strains
• Receptors, GABA-A (drug effects)
• Restraint, Physical
• Stomach Ulcer (pathology, prevention & control)
• Stress, Physiological (physiopathology)