Abstract |
High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). PDGFRA is expressed in glioma cells, whereas PDGFRB is mostly restricted to the glioma-associated stroma. Here we show that the spatial location of TAMMs correlates with the expansion of a subset of tumor cells that have acquired expression of PDGFRB in both mouse and human low-grade glioma and HCGs. Furthermore, M2-polarized microglia but not bone marrow (BM)-derived macrophages (BMDMs) induced PDGFRB expression in glioma cells and stimulated their migratory capacity. These findings illustrate a heterotypic cross-talk between microglia and glioma cells that may enhance the migratory and invasive capacity of the latter by inducing PDGFRB.
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Authors | Tatjana Wallmann, Xing-Mei Zhang, Majken Wallerius, Sara Bolin, Anne-Laure Joly, Caroline Sobocki, Lina Leiss, Yiwen Jiang, Jonas Bergh, Eric C Holland, Per Ø Enger, John Andersson, Fredrik J Swartling, Hrvoje Miletic, Lene Uhrbom, Robert A Harris, Charlotte Rolny |
Journal | iScience
(iScience)
Vol. 9
Pg. 71-83
(Nov 30 2018)
ISSN: 2589-0042 [Electronic] United States |
PMID | 30384135
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved. |