Effects of experimental acute pancreatitis in dogs on metabolism of lung surfactant phosphatidylcholine.

Abstract

Acute haemorrhagic pancreatitis was produced in the dogs by transduodenal injection of autologous bile into the main pancreatic duct. There was no significant change in the activity of three regulatory enzymes of phosphatidylcholine biosynthesis (glycerophosphate acyltransferase, cytidyltransferase and cholinephosphotransferase) in lung; however, there was a 42% decrease in the amount of dipalmitoyl phosphatidylcholine (surfactant) in lung lavage due to acute pancreatitis. The decrease in lavage phospholipid content was associated with 5-fold increase in phospholipase A2 activity of lung lavage, and massive accumulation of osmiophilic spheroid structures in the alveolar space.

• Authors: S K Das, M T Scott, S McCuiston
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 145 Issue 1 Pg. 612-8 (May 29 1987) ISSN: 0006-291X [Print] United States
• PMID: 3036136 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Phospholipids
• Pulmonary Surfactants
• 1,2-Dipalmitoylphosphatidylcholine
• Glycerol-3-Phosphate O-Acyltransferase
• Nucleotidyltransferases
• Choline-Phosphate Cytidylyltransferase
• Diacylglycerol Cholinephosphotransferase
• Phospholipases A
• Phospholipases A2

Topics

• 1,2-Dipalmitoylphosphatidylcholine (metabolism)
• Acute Disease
• Animals
• Choline-Phosphate Cytidylyltransferase
• Diacylglycerol Cholinephosphotransferase (metabolism)
• Dogs
• Glycerol-3-Phosphate O-Acyltransferase (metabolism)
• Lung (metabolism, ultrastructure)
• Nucleotidyltransferases (metabolism)
• Pancreatitis (metabolism, pathology)
• Phospholipases A (metabolism)
• Phospholipases A2
• Phospholipids (metabolism)
• Pulmonary Surfactants (metabolism)