[Behavioral pharmacological action of Ca-4-(3,5-dihydroxy-3-methylpenthylamido) butyrate (mevalonic GABA, MV-GABA)].

Abstract

The behavioral pharmacological effects of Ca-4-(3,5-dihydroxy-3-methylpenthylamido) butyrate (mevalonic-GABA, MV-GABA), a new GABA derivative were studied in comparison with those of Ca-hopantenate (HOPA) in mice. MV-GABA had no effect on the general behavior and electric shock-induced fighting behavior. The dosage of MV-GABA which caused locomotor hypoactivity produced an impairment of the rotarod performance. MV-GABA inhibited the hyperactivity induced by a dopamine (DA) agonist (methamphetamine) and acetylcholine (ACh) antagonists (scopolamine and atropine) at a dose which did not affect locomotor activity in normal mice. MV-GABA prolonged the pentobarbital-Na-induced sleeping time, and it prolonged the latencies until convulsion and death after administration of strychnine. MV-GABA and HOPA antagonized the electroconvulsive shock-induced amnesia in the passive avoidance response of mice. These results suggest that MV-GABA has effects on the central nervous systems, in particular, ACh and DA neural systems. The actions of MV-GABA were qualitatively similar to those of HOPA except for the effect on the DA neural system.

• Authors: T Kameyama, T Nabeshima, Y Noda
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 89 Issue 3 Pg. 103-10 (Mar 1987) ISSN: 0015-5691 [Print] Japan
• PMID: 3034749 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• mevalonic-GABA
• pantogab
• Pantothenic Acid
• Methamphetamine
• gamma-Aminobutyric Acid
• Mevalonic Acid
• Dopamine

Topics

• Agonistic Behavior (drug effects)
• Animals
• Anticonvulsants
• Behavior, Animal (drug effects)
• Central Nervous System (drug effects)
• Cholinergic Fibers (drug effects)
• Dopamine (physiology)
• Male
• Methamphetamine (antagonists & inhibitors)
• Mevalonic Acid (analogs & derivatives, pharmacology)
• Mice
• Motor Activity (drug effects)
• Motor Skills (drug effects)
• Pantothenic Acid (analogs & derivatives, pharmacology)
• Sleep (drug effects)
• Synaptic Transmission (drug effects)
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)