Abstract |
(+)- Tifluadom injected i.p. produced a biphasic response of urine output: within the first hour of its administration the drug produced antidiuresis followed by a diuretic phase. In contrast, the (-) isomer produced a modest reduction in urine output as compared to the output of the saline-treated rats. In addition, (+)- tifluadom markedly reduced the output of urinary Na+ and K+. The effects of (+)- tifluadom were blocked by 7.5 mg/kg naloxone but not by 10 mg/kg of the benzodiazepine antagonist Ro 15-1788. Parallel experiments demonstrated that the i.v. administration of (+)- tifluadom to non-anesthetized rats caused a dose-related pressor response that lasted for at least 15 min. This effect of (+)- tifluadom was blocked and antagonized by naloxone. In contrast, (-)- tifluadom was either inactive on the cardiovascular system or produced short-lasting hypotension. In pentobarbital-anesthetized rats, 100 micrograms/kg (+)- tifluadom caused a precipitous hypotension that was reversed by naloxone but not by Ro 15-1788.
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Authors | H Ureta, L F López, A Pérez, J P Huidobro-Toro |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 135
Issue 3
Pg. 289-95
(Mar 31 1987)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 3034631
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Electrolytes
- Receptors, Opioid
- Receptors, Opioid, kappa
- Benzodiazepines
- Naloxone
- tifluadom
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Topics |
- Anesthesia
- Animals
- Benzodiazepines
(pharmacology)
- Blood Pressure
(drug effects)
- Diuresis
(drug effects)
- Electrolytes
(urine)
- Female
- Hemodynamics
(drug effects)
- Naloxone
(pharmacology)
- Rats
- Rats, Inbred Strains
- Receptors, Opioid
(drug effects, metabolism)
- Receptors, Opioid, kappa
- Stereoisomerism
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