Abstract | AIM: METHOD: All related studies were retrieved and screened from PubMed, CNKI and Web of Science. Pooled odds ratios ( ORs) and 95% CIs were assessed for the strength of association between NRAMP1 and RA. Publication bias was measured by Begg's funnel plot and Egger's regression test. The robustness of this meta-analysis was detected by sensitivity analysis. RESULTS: A total of five eligible publications were included in the present meta-analysis. The polled data showed no association between RA and NRAMP1 D543N and 1729 + 55del4 in the allele model. However, the relationship between RA and NRAMP1 INT4 was statistically significant (OR 1.65, 95% CI 1.14-2.38). Genotypic analysis demonstrated that there were no associations between RA and NRAMP1 D543N, 1729 + 55del4 and INT4 in homozygous comparison (D543N: OR 0.97, 95% CI 0.15-6.09; 1729 + 55del4: OR 1.19, 95% CI 0.29-24.88; INT4: OR 3.18, 95% CI 0.62-16.26), dominant model (D543N: OR 1.04, 95% CI 0.61-61.78; 1729 + 55del4: OR 1.41, 95% CI 0.81-2.47; INT4: OR 1.22, 95% CI 0.72-2.06) and recessive model (D543N: OR 0.93, 95% CI 0.15-5.91; 1729 + 55del4: OR 0.99, 95% CI 0.26-3.86; INT4: OR 2.95, 95% CI 0.61-14.16). In heterozygous comparison, it no association was shown between RA and NRAMP1 D543N and INT4, excepting NRAMP1 1729 + 55del4 (OR 1.73, 95% CI 1.17-2.56). Further subgroup analysis indicated that NRAMP1 1729 + 55del4 and INT4 were related to RA in Asia and in the Hardy-Weinberg equilibrium group. There exists no publication bias in this meta-analysis. CONCLUSION: This meta-analysis indicated that NRAMP1 1729 + 55del4 and INT4 confer susceptibility to RA.
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Authors | Hong Wang, Fei-Fei Yuan, Zi-Wei Dai, Bin Wang, Dong-Qing Ye |
Journal | International journal of rheumatic diseases
(Int J Rheum Dis)
Vol. 21
Issue 9
Pg. 1651-1658
(Sep 2018)
ISSN: 1756-185X [Electronic] England |
PMID | 30345642
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © 2018 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Cation Transport Proteins
- natural resistance-associated macrophage protein 1
|
Topics |
- Arthritis, Rheumatoid
(diagnosis, genetics)
- Case-Control Studies
- Cation Transport Proteins
(genetics)
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Phenotype
- Polymorphism, Genetic
- Risk Factors
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