Healthcare resource use in XALIA: A subgroup analysis of a non-interventional study of rivaroxaban versus standard anticoagulation for deep vein thrombosis.

Abstract

INTRODUCTION:

The non-interventional XALIA study compared the safety and effectiveness of rivaroxaban with standard anticoagulation for the treatment of venous thromboembolism in routine clinical practice. This substudy assessed the effect of treatment with rivaroxaban on healthcare resource use, hospital length of stay (LOS) and frequency of hospitalisation.

METHODS:

In XALIA, patients aged ≥18 years scheduled to receive ≥3 months of rivaroxaban or standard anticoagulation treatment for deep vein thrombosis (DVT) were eligible. Treatment decisions were at the physician's discretion. Healthcare resource use, including hospital admission for the index DVT and initial LOS, was documented. The main analyses in this substudy were conducted in a 1:1 propensity score-matched set (PMS) of patients, with adjustment for cancer at baseline.

RESULTS:

In the PMS analysis, 1124 rivaroxaban-treated patients and 1124 standard anticoagulation-treated patients were included. Baseline characteristics were similar between groups (mean age 60.8 years vs. 61.2 years, DVT only rates of 89.7% vs. 90.2% and cancer rates of 8.4% vs. 8.5%, respectively). Of these, 433/1124 (38.5%) rivaroxaban-treated patients and 438/1124 (39.0%) standard anticoagulation-treated patients were hospitalised. Index event LOS in the PMS analysis was a least-squares mean of 2.6 days shorter with rivaroxaban vs. standard anticoagulation (5.4 vs. 8.0 days; geometric means ratio = 0.67 [95% confidence interval 0.61-0.74, P < 0.001]).

CONCLUSIONS:

In XALIA, hospital LOS was shorter with rivaroxaban than with standard anticoagulation, consistent with the phase III study results. DVT treatment with rivaroxaban in routine clinical practice may reduce the cost per patient vs. standard anticoagulation.

• Authors: Lorenzo G Mantovani, Sylvia Haas, Reinhold Kreutz, Kerstin Folkerts, Martin Gebel, Danja Monje, Jonas Schneider, Martin van Eickels, Kurtulus Sahin, Elizabeth Zell, Walter Ageno, Alexander G G Turpie
• Journal: European journal of internal medicine (Eur J Intern Med) Vol. 61 Pg. 29-33 (03 2019) ISSN: 1879-0828 [Electronic] Netherlands
• PMID: 30342973 (Publication Type: Comparative Study, Journal Article, Multicenter Study)
• Copyright: Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Anticoagulants
• Rivaroxaban

Topics

• Adult
• Aged
• Anticoagulants (therapeutic use)
• Blood Coagulation
• Europe
• Female
• Health Resources
• Humans
• Length of Stay (statistics & numerical data)
• Male
• Middle Aged
• Patient Readmission (statistics & numerical data)
• Propensity Score
• Pulmonary Embolism (drug therapy)
• Rivaroxaban (adverse effects, therapeutic use)
• Venous Thromboembolism (chemically induced)
• Venous Thrombosis (drug therapy)