Abstract |
GP11 had been reported to have effectively anti- tumor activity by improving the immune function in our previous study. To avoid drawbacks of the 5-Fu, GP11 in combination with 5-Fu was investigated in this study. The results demonstrated that such synergism displayed enhance the anti- tumor activity of 5-Fu. Additionally, a strength effect was also observed in regulating immune function of GP11 and 5-Fu simultaneous administration, such as enhancing serum interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) secretion, and increasing immune organs weights. Moreover, GP11 could improve the haematological and biochemical parameters deterioration, superoxide dismutase (SOD) activities reduction and malondialdehyde (MDA) levels enhancement in non-immune organs induced by 5-Fu. All these results illustrated that GP11 exhibited attenuated and synergized effect on 5-Fu by improving the immune function. It could be developed as an auxiliary preparation for chemotherapeutic drugs.
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Authors | Guang-Hua Mao, Zhe-Han Zhang, Fan Fei, Yang-Yang Ding, Wei-Jie Zhang, Hui Chen, Sameh Samir Ali, Ting Zhao, Wei-Wei Feng, Xiang-Yang Wu, Liu-Qing Yang |
Journal | International journal of biological macromolecules
(Int J Biol Macromol)
Vol. 121
Pg. 930-935
(Jan 2019)
ISSN: 1879-0003 [Electronic] Netherlands |
PMID | 30342137
(Publication Type: Journal Article)
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Copyright | Copyright © 2018. Published by Elsevier B.V. |
Chemical References |
- Antineoplastic Agents
- Fungal Polysaccharides
- Interleukin-2
- Tumor Necrosis Factor-alpha
- Superoxides
- Malondialdehyde
- Fluorouracil
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Drug Interactions
- Female
- Fluorouracil
(pharmacology)
- Fungal Polysaccharides
(pharmacology)
- Grifola
(chemistry)
- Interleukin-2
(blood)
- Malondialdehyde
(metabolism)
- Mice
- Mice, Inbred ICR
- Neoplasms
(blood, metabolism, pathology)
- Organ Size
(drug effects)
- Superoxides
(metabolism)
- Tumor Necrosis Factor-alpha
(blood)
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