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Effect of Grifola frondosa polysaccharide on anti-tumor activity in combination with 5-Fu in Heps-bearing mice.

Abstract
GP11 had been reported to have effectively anti-tumor activity by improving the immune function in our previous study. To avoid drawbacks of the 5-Fu, GP11 in combination with 5-Fu was investigated in this study. The results demonstrated that such synergism displayed enhance the anti-tumor activity of 5-Fu. Additionally, a strength effect was also observed in regulating immune function of GP11 and 5-Fu simultaneous administration, such as enhancing serum interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) secretion, and increasing immune organs weights. Moreover, GP11 could improve the haematological and biochemical parameters deterioration, superoxide dismutase (SOD) activities reduction and malondialdehyde (MDA) levels enhancement in non-immune organs induced by 5-Fu. All these results illustrated that GP11 exhibited attenuated and synergized effect on 5-Fu by improving the immune function. It could be developed as an auxiliary preparation for chemotherapeutic drugs.
AuthorsGuang-Hua Mao, Zhe-Han Zhang, Fan Fei, Yang-Yang Ding, Wei-Jie Zhang, Hui Chen, Sameh Samir Ali, Ting Zhao, Wei-Wei Feng, Xiang-Yang Wu, Liu-Qing Yang
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 121 Pg. 930-935 (Jan 2019) ISSN: 1879-0003 [Electronic] Netherlands
PMID30342137 (Publication Type: Journal Article)
CopyrightCopyright © 2018. Published by Elsevier B.V.
Chemical References
  • Antineoplastic Agents
  • Fungal Polysaccharides
  • Interleukin-2
  • Tumor Necrosis Factor-alpha
  • Superoxides
  • Malondialdehyde
  • Fluorouracil
Topics
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Drug Interactions
  • Female
  • Fluorouracil (pharmacology)
  • Fungal Polysaccharides (pharmacology)
  • Grifola (chemistry)
  • Interleukin-2 (blood)
  • Malondialdehyde (metabolism)
  • Mice
  • Mice, Inbred ICR
  • Neoplasms (blood, metabolism, pathology)
  • Organ Size (drug effects)
  • Superoxides (metabolism)
  • Tumor Necrosis Factor-alpha (blood)

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