Murine cytomegalovirus.

Abstract

BALB/c and C57BL/6 mice were infected with murine cytomegalovirus (MCMV). On day 4 or 12 of the infection, the animals were immunized with SRBC (T-dependent), TNP-Ficoll (T-independent) and standard poliovirus. The adverse effect of the virus infection on humoral immune responses was limited to animals immunized on day 4; while anti-SRBC antibody formation was severely depressed in both mouse strains, reduced plaque forming cells to TNP-Ficoll were registered only in BALB/c mice. Antibodies to poliovirus were depressed in both strains, although to a lesser degree in C57Bl/6 than in BALB/c mice. Anti-SRBC B cell memory was found to be affected by MCMV infection. These results are interpreted to mean that T-dependent and -independent antigens may be handled differently by the two mouse strains tested.

• Authors: U Schilt
• Journal: Immunobiology (Immunobiology) Vol. 174 Issue 1 Pg. 10-9 (Jan 1987) ISSN: 0171-2985 [Print] Netherlands
• PMID: 3032777 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Viral

Topics

• Animals
• Antibodies, Viral (biosynthesis)
• Antibody Formation
• B-Lymphocytes (immunology)
• Cytomegalovirus Infections (complications, immunology)
• Erythrocytes (immunology)
• Female
• Immunization
• Immunologic Deficiency Syndromes (etiology, immunology)
• Immunologic Memory
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Poliovirus (immunology)
• Sheep
• Virus Cultivation