[Phosphatidylcholine-induced repair of damaged hepatocyte membranes in heliotrine poisoning].

Abstract

Hepatocyte membranes destruction in experimental toxic hepatitis caused by heliotrine administration was accompanied by a 10-fold increase in blood serum activity of aldolase fructose-I-monophosphate, a decrease in cytochrome P-450 content, an increase in the rate of cytochrome P-450 inactivation, as well as a decrease in microsomal glucose-6-phosphatase activity. Administration of phosphatidylcholine liposomes decreased the activity of aldolase twofold, which indirectly shows partial reconstitution of liver cell membranes. Phosphatidylcholine protective action is also manifested in an increase in the activity of glucose-6-phosphatase, a microsomal marker enzyme, up to its control level and in a 20% reduced rate of cytochrome P-450 inactivation. It has been shown that destroyed liver cell membranes may be repaired by the introduction of phosphatidylcholine in the form of multilayer liposomes.

• Authors: O V Dobrynina, S Z Shatinina, A I Archakov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 103 Issue 4 Pg. 413-5 (Apr 1987) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Reparatsiia fosfatidilkholinom povrezhdennykh membran gepatotsitov pri otravlenii geliotrinom.
• PMID: 3032300 (Publication Type: Journal Article)

Chemical References

• Liposomes
• Phosphatidylcholines
• Pyrrolizidine Alkaloids
• Cytochrome P-450 Enzyme System
• Glucose-6-Phosphatase
• Fructose-Bisphosphate Aldolase
• heliotrine

Topics

• Animals
• Cell Membrane (drug effects, enzymology, metabolism)
• Chemical and Drug Induced Liver Injury (enzymology, metabolism, prevention & control)
• Cytochrome P-450 Enzyme System (metabolism)
• Enzyme Activation
• Fructose-Bisphosphate Aldolase (blood)
• Glucose-6-Phosphatase (metabolism)
• Liposomes
• Male
• Microsomes, Liver (enzymology, metabolism)
• Phosphatidylcholines (pharmacology)
• Pyrrolizidine Alkaloids (poisoning)
• Rats