Socket Reconstruction With Bleomycin, Gentamicin, and Gelatin Sponges Following Eyelid-Sparing Orbital Exenteration for a Colobomatous Macrocyst in an Infant.

Abstract

Microphthalmia is defined by a globe axial length greater than or equal to 2 standard deviations below the age-adjusted mean and can occur as part of a broader syndrome. The presence of a colobomatous cyst with microphthalmia signifies failure of the embryonic neuroectodermal fissure to close appropriately during development of the globe, creating a protuberant globular appendage that inhibits normal growth and development of the eye itself. Cystic reaccumulation of fluid is common after aspiration or surgical removal. Here, the authors describe a case of a young boy with a colobomatous cyst who underwent eyelid-sparing orbital exenteration followed by reconstruction with absorbable gelatin sponge (Gelfoam, Pfizer, Inc.) and the chemotherapeutic agent bleomycin to promote scarring, achieving the equivalent of a biointegrated implant and facilitating satisfactory placement of an ocular prosthesis. A 2-year follow-up MRI revealed adequate volume in the posterior orbit.

• Authors: Sarah J Michelson, Marina R Ciongoli, Victor M Elner, Alon Kahana
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2018 Nov/Dec Vol. 34 Issue 6 Pg. e201-e203 ISSN: 1537-2677 [Electronic] United States
• PMID: 30320716 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Drug Combinations
• Gentamicins
• Bleomycin
• Gelatin

Topics

• Antibiotics, Antineoplastic (pharmacology)
• Biopsy
• Bleomycin (pharmacology)
• Coloboma (diagnosis, surgery)
• Cysts (diagnosis, surgery)
• Drug Combinations
• Eye Neoplasms (diagnosis, surgery)
• Eye, Artificial
• Gelatin (pharmacology)
• Gentamicins (pharmacology)
• Humans
• Infant, Newborn
• Magnetic Resonance Imaging
• Male
• Orbit (diagnostic imaging, surgery)
• Orbit Evisceration (methods)
• Plastic Surgery Procedures (methods)
• Surgical Sponges