| Abstract | The object of this study was to evaluate the effectiveness of the immuno-suppressor Azathioprine (AZ) on chronic and severe pulmonary sarcoidosis, with a persistent activity resistant to prolonged corticotherapy. The study was done on 10 patients (4 women, 6 men) afflicted by an histologically proven and chronic sarcoidosis, resistant to steroid treatment. The treatment consisted of a daily oral intake of 150 mg of AZ for six months. Its effectiveness was evaluated before and after treatment, in comparison with a control group and a steroid-treated group of sarcoid patients. Serologic and alveolar functional and immuno-biologic tests were performed in 8 cases according to the activity criteria defined at the IXth International Congress on sarcoidosis. No clinical or hematological side effects were observed; a clear and prolonged radiological and clinical amelioration was observed in 7 out of 10 cases and in 3 cases a restoration of sensibility to the tuberculin skin test; in the 8 cases a significant improvement (p less than 0.01) was noted after the sixth month of treatment only in the alveolar fluid in the following parameters: ACE, all the proteins studied and the percentage of lymphocytes. |
| Authors | Y Pacheco, C Marechal, F Marechal, N Biot, M Perrin Fayolle |
| Journal | Sarcoidosis
(Sarcoidosis)
Vol. 2
Issue 2
Pg. 107-13
(Sep 1985)
ISSN: 0393-1447 ITALY |
| PMID | 3031790
(Publication Type: Journal Article)
|
| Chemical References |
- alpha 1-Antitrypsin
- Azathioprine
- Muramidase
- Peptidyl-Dipeptidase A
|
| Topics |
- Adult
- Azathioprine
(therapeutic use)
- Drug Evaluation
- Female
- Humans
- Lung Diseases
(blood, drug therapy)
- Lymphocytes
(drug effects)
- Male
- Muramidase
(blood)
- Peptidyl-Dipeptidase A
(blood)
- Sarcoidosis
(blood, drug therapy)
- alpha 1-Antitrypsin
(blood)
|
