Effect of various polybrominated biphenyls on cell-cell communication in cultured human teratocarcinoma cells.

Abstract

Firemaster BP-6 (FM), a mixture of polybrominated biphenyls (PBB), and the congeners 2,2',4,4',5,5'-hexabromobiphenyl (245-HBB), 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB), and 3,3',4,4'-tetrabromobiphenyl (34-TBB) were tested for their ability to inhibit cell-cell communication between human teratocarcinoma cells in culture. Both FM and 245-HBB were capable of inhibiting cell-cell communication in these cells, with only slight effects on cell survival. 345-HBB was highly cytotoxic, but did not show the ability to interrupt cell-cell communication. 34-TBB was moderately cytotoxic and was also ineffective at blocking cell-cell communication. The results agree with previously published findings in Chinese hamster V79 cells, and are in accordance with proposed structure-activity relationships for these compounds. Inhibition of cell-cell communication, either directly (FM and 245-HBB) or indirectly through necrosis-induced compensatory hyperplasia (345-HBB), may be involved in the promotion of hepatocellular neoplasms by these compounds.

• Authors: T J Kavanagh, C C Chang, J E Trosko
• Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology (Fundam Appl Toxicol) Vol. 8 Issue 1 Pg. 127-31 (Jan 1987) ISSN: 0272-0590 [Print] United States
• PMID: 3030867 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Polybrominated Biphenyls
• Receptors, Aryl Hydrocarbon
• Receptors, Drug

Topics

• Cell Communication (drug effects)
• Cells, Cultured
• Humans
• Polybrominated Biphenyls (metabolism, toxicity)
• Receptors, Aryl Hydrocarbon
• Receptors, Drug (drug effects)
• Structure-Activity Relationship
• Teratoma (metabolism, pathology)