Abstract | BACKGROUND/AIMS: MATERIALS AND METHODS: A total of 100 patients with MSAP were randomized to receive either standard care (SC) or SC plus LMWH. LMWH was administered at 1 mg/kg via subcutaneous injection twice a day between days 1 and 7. The revised Atlanta criteria were used in the diagnosis of MSAP. Patients with a Harmless AP Score of >1 and a Balthazar computed tomography (CT) score of D and E were included in the study. RESULTS: The mean age±SD of the patients (46 male and 54 female) was 52±19 years (range, 17-100). There were 50 patients in each group. On admission, clinical and laboratory parameters and Balthazar CT scores were similar between the groups. Initially, PN was present in one patient in the LMWH group and two in the SC group. Over the course, PN developed in 3 (6.1%) patients in the LMWH group and 11 (22.9%) in the SC group (p<0.05). Local and systemic complications were significantly lower in the LMWH group (p<0.05). No hemorrhagic complication occurred. Mortality was not significantly different between the groups (p=0.056). CONCLUSION:
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Authors | Mukaddes Tozlu, Yusuf Kayar, Ali Tüzün İnce, Birol Baysal, Hakan Şentürk |
Journal | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
(Turk J Gastroenterol)
Vol. 30
Issue 1
Pg. 81-87
(01 2019)
ISSN: 2148-5607 [Electronic] Turkey |
PMID | 30289392
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anticoagulants
- Heparin, Low-Molecular-Weight
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Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anticoagulants
(therapeutic use)
- Female
- Heparin, Low-Molecular-Weight
(therapeutic use)
- Humans
- Male
- Middle Aged
- Necrosis
(prevention & control)
- Pancreas
(pathology)
- Pancreatitis
(complications, drug therapy, pathology)
- Prognosis
- Severity of Illness Index
- Treatment Outcome
- Young Adult
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