Shear wave elastography prior to transjugular intrahepatic portosystemic shunt may predict the decrease in hepatic vein pressure gradient.

Abstract

BACKGROUND:

Transjugular intrahepatic portosystemic shunt (TIPS) is a procedure used to treat portal hypertension complications. Our aim was to evaluate liver and spleen stiffness measurement (LSM and SSM, respectively) changes using acoustic radiation force impulse imaging (ARFI) in comparison to Child-Pugh scores for predicting hepatic venous pressure gradient (HVPG) decreases after TIPS implantation.

METHODS:

This prospective study included 31 consecutive clinically significant portal hypertension patients with TIPS indication. All patients received LSM and SSM before TIPS, at baseline, 2 days (follow-up 1) and 6 weeks (follow-up 2) post-implantation. HVPG was performed during the TIPS procedure.

RESULTS:

The mean decrease in HVPG after TIPS was 63%. LSM and SSM decreased significantly between baseline and follow-up 2 (p < 0.001 and p < 0.001, respectively). At baseline, follow-up 1 and follow-up 2, significant correlations were detected between mean SSM and mean HVPG (p = 0.026; p = 0.018; p = 0.002, respectively). HVPG decreased to ≤ 10 mmHg in 61% of patients for which LSM, SSM, and Child-Pugh score were predictors (p = 0.033, p = 0.002 and p = 0.030, respectively). The area under the curve (AUC) for LSM, SSM, and Child-Pugh was 0.88, 0.90, and 0.84, respectively, with close sensitivity and specificity. SSM had the highest diagnostic accuracy for predicting an HVPG decrease to ≤ 10 mmHg in comparison to LSM and Child-Pugh score.

CONCLUSION:

Spleen stiffness is superior to liver stiffness and Child-Pugh score as a non-invasive surveillance tool for evaluating patients with clinically significant portal hypertension (HVPG ≥ 10 mmHg) prior to TIPS.

• Authors: Dina Attia, Thomas Rodt, Steffen Marquardt, Jan Hinrichs, Bernhard C Meyer, Michael Gebel, Frank Wacker, Michael P Manns, Andrej Potthoff
• Journal: Abdominal radiology (New York) (Abdom Radiol (NY)) Vol. 44 Issue 3 Pg. 1127-1134 (03 2019) ISSN: 2366-0058 [Electronic] United States
• PMID: 30288582 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Elasticity Imaging Techniques (methods)
• Female
• Hemodynamics
• Hepatic Veins
• Humans
• Hypertension, Portal (diagnostic imaging, surgery)
• Male
• Middle Aged
• Portal Pressure
• Portasystemic Shunt, Transjugular Intrahepatic
• Prospective Studies
• Sensitivity and Specificity
• Spleen (diagnostic imaging)