Pagetoid reticulosis, epidermotropic mycosis fungoides and mycosis fungoides: a disease spectrum.

Abstract

Using a standard technique involving monoclonal antibodies against T-cell subsets, we have shown that almost all the infiltrating T-cells in the epidermis of a patient with Pagetoid reticulosis (PR), one with epidermotropic mycosis fungoides (EMF) and one with poikiloderma atrophicans vasculare (PAV), were OKT8 positive (presumed cytotoxic/suppressor) T-cells. The infiltrating T-cells in the epidermis of a patient with limited plaque stage mycosis fungoides (MF), however, were almost exclusively Leu 3a-positive (presumed helper/inducer) T-cells as is usually found in this condition. The keratinocytes in the patients with PR, EMF and PAV were HLA-DR-positive whilst those in the patient with MF were HLA-DR-negative. We consider these four diseases to be part of the spectrum of mycosis fungoides, the first three conditions representing the early or benign end of the spectrum.

• Authors: R S Tan, T I MacLeod, S G Dean
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 116 Issue 1 Pg. 67-77 (Jan 1987) ISSN: 0007-0963 [Print] England
• PMID: 3028465 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal

Topics

• Adult
• Aged
• Antibodies, Monoclonal
• Female
• Histocytochemistry
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Mycosis Fungoides (pathology)
• Paget Disease, Extramammary (pathology)
• Skin Neoplasms (pathology)