Internalization capabilities of gold-198 nanoparticles: Comparative evaluation of effects of chitosan agent on cellular uptake into MCF-7.

Abstract

In this study, internalization of positively charged chitosan-coated nanoparticles (198AuNPs@chitosan) on MCF-7 cells was investigated by γ-ray spectroscopy and then statistically compared to that of 198Au and negatively charged citrate-stabilized nanoparticles (198AuNPs). Sub-50 nm 198AuNPs@chitosan had a higher internalization compared to 198Au and 198AuNPs (p < 0.05). More cellular uptake of 198AuNP@chitosan means a higher dose of radioactivity to the tumor cells which, in turn, more effective treatment of the cancer.

• Authors: Mohammad Reza Aboudzadeh Rovais, Behrouz Alirezapour, Mohammad Esmaeil Moassesi, Mojtaba Amiri, Fatemeh Bolouri Novin, Ehsan Maadi
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 142 Pg. 85-91 (Dec 2018) ISSN: 1872-9800 [Electronic] England
• PMID: 30273763 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Coated Materials, Biocompatible
• Gold Radioisotopes
• Radiopharmaceuticals
• Gold-198
• Chitosan

Topics

• Biological Transport, Active
• Breast Neoplasms (metabolism, radiotherapy)
• Chitosan (administration & dosage, chemistry)
• Coated Materials, Biocompatible (administration & dosage, chemistry)
• Drug Delivery Systems
• Endocytosis
• Exocytosis
• Female
• Gold Radioisotopes (administration & dosage, chemistry, pharmacokinetics)
• Humans
• MCF-7 Cells
• Metal Nanoparticles (administration & dosage, chemistry)
• Nanotechnology
• Particle Size
• Radiopharmaceuticals (administration & dosage, chemistry, pharmacokinetics)
• Spectrometry, Fluorescence
• Spectroscopy, Fourier Transform Infrared
• Surface Properties