Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.

Abstract

Despite the claim that encapsulation of drugs improves the therapeutic profile of free drugs, there are still important limitations in drug delivery. With respect to cancer treatment, two promising implementations are combination therapy and targeted devices, which are aimed at increasing the drug effect either by achieving higher cell death rates or by discriminating between cell populations. However, for the time being, the scope of combining both approaches is unknown. To advance this knowledge, a two-drug-delivery system with dual cell-organelle targeting based on mesoporous silica nanoparticles, which are known to be able to host drugs within their pores, has been designed. In vitro results show a synergistic effect and high efficacy, demonstrating that the combination of dual therapy and targeting could still advance the development of drug-delivery nanodevices against difficult-to-treat cancers.

• Authors: Rafael R Castillo, Daniel Lozano, María Vallet-Regí
• Journal: Bioconjugate chemistry (Bioconjug Chem) Vol. 29 Issue 11 Pg. 3677-3685 (11 21 2018) ISSN: 1520-4812 [Electronic] United States
• PMID: 30273483 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (administration & dosage, therapeutic use)
• Cell Membrane (chemistry)
• Drug Delivery Systems
• Humans
• Nanoparticles (therapeutic use)
• Neoplasms (drug therapy)
• Organelles (chemistry)