Efficiency of Single Dose of Tolvaptan Treatment During the Triphasic Episode After Surgery for Craniopharyngioma

Abstract

Inappropriate antidiuretic hormone syndrome (SIADH) may develop after intracranial surgery. SIADH in the pediatric age group is usually encountered in patients with an intracranial mass both before and after surgery. Fluid restriction is the standard therapy in SIADH. However, a resistant, hyponatremic pattern may be encountered in some cases. Vaptans have been recently introduced for treatment of hyponatremia due to SIADH. There is inadequate data concerning tolvaptan treatment in pediatric patients. We present a 13 year-old female with SIADH of triphasic episode who was transferred to our clinic after surgery for craniopharyngioma. Resistant hyponatremia did not resolve despite fluid restriction and hypertonic saline support. The patient responded rapidly to a single dose of tolvaptan, with no adverse effect, which resulted in successful control of her SIADH.

• Authors: Fatih Gürbüz, Mehmet Taştan, İhsan Turan, Bilgin Yüksel
• Journal: Journal of clinical research in pediatric endocrinology (J Clin Res Pediatr Endocrinol) Vol. 11 Issue 2 Pg. 202-206 (05 28 2019) ISSN: 1308-5735 [Electronic] Turkey
• PMID: 30257818 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antidiuretic Hormone Receptor Antagonists
• Tolvaptan

Topics

• Adolescent
• Antidiuretic Hormone Receptor Antagonists (therapeutic use)
• Craniopharyngioma (pathology, surgery)
• Female
• Humans
• Hyponatremia (drug therapy, etiology, pathology)
• Inappropriate ADH Syndrome (complications, physiopathology)
• Neurosurgical Procedures (adverse effects)
• Pituitary Neoplasms (pathology, surgery)
• Postoperative Complications (drug therapy, etiology, pathology)
• Prognosis
• Tolvaptan (therapeutic use)