[Effect of chemotherapy on the nucleoside phosphate kinase activity in experimental tumors].

Abstract

In animals with experimental transplantable tumors, an effective treatment with antitumor compounds brought about interrelated changes in nucleoside phosphate kinase activity. The decrease in thymidine phosphate kinase activity was as a rule matched by an increase in that of uridine phosphate kinase. Consequently, "thymidine kinase-uridine kinase" shunt responsible for thymidine-uridine interconversion was suggested, which is switched on when the homeostasis of tumor cells is disturbed. In treatment of tumor-bearing animals, the effective dosage of antitumor drugs was considerably decreased due to a combination of the said compounds (inhibiting nucleoside kinases) or with azauridine which inhibits uridine monophosphate synthesis from orotidine-5'-phosphate.

• Authors: A V Tret'iakov, V A Filov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 32 Issue 11 Pg. 95-8 ( 1986) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Vliianie khimioterapii na nukleozidfosfatkinaznuiu aktivnost' éksperimental'nykh opukholeĭ.
• PMID: 3024413 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Phosphotransferases
• Thymidine Kinase
• Uridine Kinase

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Male
• Mice
• Phosphotransferases (metabolism)
• Rats
• Sarcoma, Experimental (drug therapy, enzymology)
• Thymidine Kinase (metabolism)
• Uridine Kinase (metabolism)