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Treatment of fatal disseminated vaccinia virus infection in immunosuppressed mice.

Abstract
Studies were performed to compare the therapeutic effectiveness of three antiviral drugs (ARA-A, ARA-C and IDU) on the course of fatal disseminated vaccinia virus infection in immunosuppressed mice. Treatment with ARA-A begun as late as 7 days after virus infection was significantly effective in preventing death; no antiviral effect of the other two drugs was demonstrated.
AuthorsM Worthington, M Conliffe
JournalThe Journal of general virology (J Gen Virol) Vol. 36 Issue 2 Pg. 329-333 (Aug 1977) ISSN: 0022-1317 [Print] England
PMID302323 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antilymphocyte Serum
  • Cytarabine
  • Vidarabine
  • Idoxuridine
Topics
  • Animals
  • Antilymphocyte Serum (therapeutic use)
  • Cytarabine (administration & dosage, therapeutic use)
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Idoxuridine (administration & dosage, therapeutic use)
  • Immunosuppression Therapy
  • Injections, Intraperitoneal
  • Mice
  • T-Lymphocytes (immunology)
  • Vaccinia (drug therapy, mortality)
  • Vidarabine (administration & dosage, therapeutic use)

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