Astatine-211: its possible applications in cancer therapy.

Abstract

The cyclotron-produced radiohalogen, 211At, is eminently suitable as a possible therapeutic radionuclide. It decays by the emission of 6.8 MeV mean energy alpha-particles, which from a radiobiological viewpoint are of near optimal therapeutic LET. This paper reviews developments in the possible application of [211At]astato-labelled molecules as potential anti-tumour agents. Additionally, radio-dosimetric evidence is presented, and its implications for human cancer therapy are discussed.

• Authors: I Brown
• Journal: International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes (Int J Rad Appl Instrum A) Vol. 37 Issue 8 Pg. 789-98 ( 1986) ISSN: 0883-2889 [Print] England
• PMID: 3021680 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Monoclonal
• Naphthoquinones
• Nucleic Acid Precursors
• Astatine

Topics

• Animals
• Antibodies, Monoclonal (therapeutic use)
• Astatine (therapeutic use)
• Humans
• Melanoma (radiotherapy)
• Naphthoquinones (therapeutic use)
• Neoplasms (radiotherapy)
• Nucleic Acid Precursors (therapeutic use)
• Radiotherapy Dosage