CEST MRI of 3-O-methyl-D-glucose uptake and accumulation in brain tumors.

Abstract

PURPOSE:

3-O-Methyl-D-glucose (3-OMG) is a nonmetabolizable structural analog of glucose that offers potential to be used as a CEST-contrast agent for tumor detection. Here, we explore it for CEST-detection of malignant brain tumors and compare it with D-glucose.

METHODS:

Glioma xenografts of a U87-MG cell line were implanted in five mice. Dynamic 3-OMG weighted images were collected using CEST-MRI at 11.7 T at a single offset of 1.2 ppm, showing the effect of accumulation of the contrast agent in the tumor, following an intravenous injection of 3-OMG (3 g/kg).

RESULTS:

Tumor regions showed higher enhancement as compared to contralateral brain. The CEST contrast enhancement in the tumor region ranged from 2.5-5.0%, while it was 1.5-3.5% in contralateral brain. Previous D-glucose studies of the same tumor model showed an enhancement of 1.5-3.0% and 0.5-1.5% in tumor and contralateral brain, respectively. The signal gradually stabilized to a value that persisted for the length of the scan.

CONCLUSIONS:

3-OMG shows a CEST contrast enhancement that is approximately twice as much as that of D-glucose for a similar tumor line. In view of its suggested low toxicity and transport properties across the BBB, 3-OMG provides an option to be used as a nonmetallic contrast agent for evaluating brain tumors.

• Authors: Akansha Ashvani Sehgal, Yuguo Li, Bachchu Lal, Nirbhay N Yadav, Xiang Xu, Jiadi Xu, John Laterra, Peter C M van Zijl
• Journal: Magnetic resonance in medicine (Magn Reson Med) Vol. 81 Issue 3 Pg. 1993-2000 (03 2019) ISSN: 1522-2594 [Electronic] United States
• PMID: 30206994 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: © 2018 International Society for Magnetic Resonance in Medicine.

Chemical References

• Contrast Media
• 3-O-Methylglucose
• Glucose

Topics

• 3-O-Methylglucose (administration & dosage, pharmacokinetics)
• Administration, Oral
• Animals
• Area Under Curve
• Blood-Brain Barrier
• Brain (diagnostic imaging)
• Brain Neoplasms (diagnostic imaging)
• Cell Line, Tumor
• Contrast Media (administration & dosage, pharmacokinetics)
• Female
• Glioma (diagnostic imaging)
• Glucose (administration & dosage, pharmacokinetics)
• Humans
• Image Processing, Computer-Assisted (methods)
• Magnetic Resonance Imaging (methods)
• Mice
• Mice, SCID
• Neoplasm Transplantation