Treatment of cryptococcal meningitis in mice with fluconazole.

Abstract

Fluconazole is a recently developed triazole with activity in vitro against Cryptococcus neoformans, water solubility, and excellent oral absorption. We compared fluconazole in murine cryptococcosis with ketoconazole and amphotericin B. Fluconazole was highly effective in suppressing cryptococcosis in mice challenged by the intravenous and intranasal routes, and was comparable with the other two drugs in its protective capacity. However, fluconazole was superior to ketoconazole and comparable with amphotericin B after intracerebral challenge. Fluconazole may warrant clinical evaluation in cryptococcosis.

• Authors: E Palou de Fernandez, M M Patino, J R Graybill, M H Tarbit
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 18 Issue 2 Pg. 261-70 (Aug 1986) ISSN: 0305-7453 [Print] England
• PMID: 3019986 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antifungal Agents
• Triazoles
• Amphotericin B
• Fluconazole
• Ketoconazole

Topics

• Amphotericin B (therapeutic use)
• Animals
• Antifungal Agents (metabolism, therapeutic use)
• Cryptococcosis (drug therapy)
• Fluconazole
• Ketoconazole (therapeutic use)
• Kinetics
• Meningitis (drug therapy)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred ICR
• Mice, Nude
• Rats
• Rats, Inbred Strains
• Triazoles (metabolism, therapeutic use)