Retrovirus-induced osteopetrosis in mice. Ultrastructural evidence of early virus production in osteoblasts and osteocytes.

Abstract

Newborn female strain NMRI mice were given injections of a mouse retrovirus (OA MuLV) known to induce osteopetrosis, osteoma, and lymphoma. Femur metaphyses and lumbar vertebrae were investigated ultrastructurally 3 d, 7 d and 28 d after infection. Budding, immature and mature virus was observed associated with osteoblasts and osteocytes, but not with osteoclasts or chondrocytes, 28 d after infection with the virus. No production of virus particles was observed in bone-tissue in mock-treated controls. Thus, the primary target cell for OA virus in bone appears to belong to the osteoblastic/osteocytic cell lineage.

• Authors: A B Murray, J Schmidt, L Rieke
• Journal: The American journal of pathology (Am J Pathol) Vol. 124 Issue 2 Pg. 319-23 (Aug 1986) ISSN: 0002-9440 [Print] United States
• PMID: 3017117 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Female
• Inclusion Bodies, Viral (ultrastructure)
• Mice
• Microscopy, Electron
• Osteoblasts (microbiology)
• Osteocytes (microbiology)
• Osteopetrosis (etiology, pathology)
• Retroviridae
• Tumor Virus Infections (ultrastructure)