Abstract |
Eravacycline is a novel, fully synthetic fluorocycline antibiotic with in vitro activity against aerobic and anaerobic Gram-positive and Gram-negative pathogens, including multidrug-resistant (MDR) bacteria. The pharmacokinetics (PK), urinary excretion, and safety/tolerability of intravenous (i.v.) eravacycline were evaluated in single- and multiple-ascending-dose studies. Healthy subjects received single i.v. doses of 0.1 to 3 mg/kg of body weight or 10 days of treatment with 0.5 or 1.5 mg/kg every 24 h (q24h) over 30 min, 1.5 mg/kg q24h over 60 min, or 1 mg/kg q12h over 60 min. After single doses, total exposure (the area under the plasma concentration-time curve [AUC]) and the maximum plasma concentrations (Cmax) of eravacycline increased in an approximately dose-proportional manner. After multiple doses, steady state was achieved within 5 to 7 days. Accumulation ranged from approximately 7% to 38% with the q24h dosing regimens and was 45% with 1 mg/kg q12h. Eravacycline was generally well tolerated, with dose-related nausea, infusion site effects, and superficial phlebitis that were mild or moderate occurring. These results provide support for the 1-mg/kg q12h regimen used in clinical studies of eravacycline.
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Authors | Joseph V Newman, Jian Zhou, Sergey Izmailyan, Larry Tsai |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 62
Issue 11
(11 2018)
ISSN: 1098-6596 [Electronic] United States |
PMID | 30150464
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Newman et al. |
Chemical References |
- Anti-Bacterial Agents
- Tetracyclines
- eravacycline
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Topics |
- Adolescent
- Adult
- Anti-Bacterial Agents
(administration & dosage, adverse effects, pharmacokinetics)
- Area Under Curve
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Half-Life
- Humans
- Male
- Middle Aged
- Tetracyclines
(administration & dosage, adverse effects, pharmacokinetics)
- Young Adult
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