Identification of protein complexes associated with myocardial infarction using a bioinformatics approach.

Abstract

Myocardial infarction (MI) is a leading cause of mortality and disability worldwide. Determination of the molecular mechanisms underlying the disease is crucial for identifying possible therapeutic targets and designing effective treatments. On the basis that MI may be caused by dysfunctional protein complexes rather than single genes, the present study aimed to use a bioinformatics approach to identifying complexes that may serve important roles in the development of MI. By investigating the proteins involved in these identified complexes, numerous proteins have been reported that are related to MI, whereas other proteins interacted with MI‑related proteins, which implied that these protein complexes may indeed be related to the development of MI. The protein complexes detected in the present study may aid in our understanding of the molecular mechanisms that underlie MI pathogenesis.

• Authors: Nianhui Jiao, Yongjie Qi, Changli Lv, Hongjun Li, Fengyong Yang
• Journal: Molecular medicine reports (Mol Med Rep) Vol. 18 Issue 4 Pg. 3569-3576 (Oct 2018) ISSN: 1791-3004 [Electronic] Greece
• PMID: 30132549 (Publication Type: Journal Article)

Chemical References

• Proteins

Topics

• Genomics
• Humans
• Myocardial Infarction (genetics, metabolism, pathology)
• Protein Interaction Maps
• Proteins (analysis, genetics, metabolism)
• Proteomics
• Recurrence