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Susceptibility of avian B lymphocytes to retroviral infection parallels that of fibroblasts.

Abstract
The ability of conventional virus receptors to mediate infection and transformation of immature B cells by the avian leukosis virus (ALV) was analyzed in chimeric chickens whose bursa of Fabricius contained a mixture of B cells from subgroup A virus receptor-positive and -negative chickens. The data indicate that factors that determine resistance of fibroblasts to ALV infection also apply to bursal cells and that other receptors expressed by B cells, i.e., antigen or mitogen receptors, do not initiate infection or transformation, at least not independent of conventional virus receptors.
AuthorsD L Ewert, C Goldstein
JournalVirology (Virology) Vol. 152 Issue 1 Pg. 262-7 (Jul 15 1986) ISSN: 0042-6822 [Print] United States
PMID3012871 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Receptors, Virus
Topics
  • Animals
  • Avian Leukosis (microbiology)
  • Avian Sarcoma Viruses (growth & development)
  • B-Lymphocytes (microbiology)
  • Bursa of Fabricius (microbiology)
  • Chickens (microbiology)
  • Chimera
  • Fibroblasts (microbiology)
  • Liver Neoplasms (secondary)
  • Receptors, Virus (physiology)

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