Superoxide anion generation during airway anaphylaxis.

Abstract

Extracellular release of superoxide anion (O-2) during in vitro anaphylaxis in guinea pig trachealis was found to exhibit both a time- and a concentration-dependent generation of O-2. Trachealis O-2 release was unaffected by treatment with diphenhydramine HCl (10(-5) M, 10(-6) M). While indomethacin (10(-5) M) augmented anaphylaxis tension it did not enhance O-2 release. However, the semiselective SRS-A antagonist FPL 55712 (10(-5) M) resulted in essentially complete inhibition of O-2 generation. These data indicate that O-2 generation occurring during acute airway anaphylaxis is associated with the activation of SRS-A products.

• Authors: E B Weiss, J R Bellino
• Journal: International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 80 Issue 2 Pg. 211-3 ( 1986) ISSN: 0020-5915 [Print] Switzerland
• PMID: 3011681 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• SRS-A
• Superoxides

Topics

• Anaphylaxis (metabolism)
• Animals
• Extracellular Space (metabolism)
• Guinea Pigs
• Male
• SRS-A (pharmacology)
• Superoxides (metabolism)
• Trachea (metabolism)