Abstract |
Heterologous live, oral rotavirus vaccines of rhesus monkey (RRV-1) and bovine (RIT 4237) origin were tested for immunogenicity, excretion of virus, and clinical reactions in six- to eight-month-old infants. Antibody response, indicating infection with the vaccine virus, was detected in 21 (88%) of 24 children receiving the RRV-1 vaccine and in 18 (75%) of 24 receiving the RIT 4237 vaccine. Excretion of virus in the stools within one week after vaccination was demonstrable in 84% of the RRV-1 and in 21% of the RIT 4237 vaccinees. RRV-1 vaccination was associated with a febrile response (over 38 C) that clustered on days 3 or 4 postvaccination in 64% of the recipient children. In addition, 20% of the RRV-1 vaccinees had watery stools on days 4 or 5. Fever on days 3 and 4 and loose stools were not seen in the RIT 4237 vaccinees. We concluded that in young children the RRV-1 (rhesus monkey) rotavirus vaccine is more immunogenic than the RIT 4237 (bovine) rotavirus vaccine, but vaccination with RRV-1 is associated with significant adverse reactions.
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Authors | T Vesikari, A Z Kapikian, A Delem, G Zissis |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 153
Issue 5
Pg. 832-9
(May 1986)
ISSN: 0022-1899 [Print] United States |
PMID | 3009634
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Antibodies, Viral
- Immunoglobulin G
- Viral Vaccines
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Topics |
- Administration, Oral
- Animals
- Antibodies, Viral
(biosynthesis)
- Cattle
- Clinical Trials as Topic
- Complement Fixation Tests
- Enzyme-Linked Immunosorbent Assay
- Feces
(microbiology)
- Humans
- Immunoglobulin G
(biosynthesis)
- Infant
- Macaca mulatta
- Neutralization Tests
- Rotavirus
(immunology, isolation & purification)
- Vaccination
- Viral Vaccines
(administration & dosage, adverse effects, immunology)
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