Promising Antituberculosis Activity of Piperine Combined with Antimicrobials: A Systematic Review.

Abstract

Piperine, a bioactive compound from Piper nigrum and Piper longum, has shown promising activity as efflux pump (EP) inhibitor and as adjunct in treatment of tuberculosis (TB). The present systematic review investigated scientific studies of the activity of piperine against mycobacteria, with a focus on its mechanism of action, drug interactions, and antimycobacterial activity. A broad and rigorous literature search of three electronic databases (PubMed, Web of Knowledge, and LILACS) was performed according to the PRISMA statement. We considered studies that were published up to December 1, 2017. Google Scholar was also searched to increase the number of publications. We searched for articles using the search terms "piperine" and "Mycobacterium spp." The search yielded a total of 225 articles. After removing duplicate publications, 208 publications remained. Of these, we evaluated the full text of 13 articles. After applying the inclusion criteria, eight studies were included in the present systematic review. The results of the systematic review showed that piperine has promising anti-TB activity, mainly when combined with antimicrobials, and plays an important role as an EP inhibitor.

• Authors: Laíse Adriane Hegeto, Katiany R Caleffi-Ferracioli, JoãoVitor Perez de Souza, Aryadne Larissa de Almeida, Sandra Sayuri Nakamura de Vasconcelos, Isabella Letícia Esteves Barros, Pedro Henrique Canezin, Paula Aline Zanetti Campanerut-Sá, Regiane Bertin de Lima Scodro, Vera Lucia Dias Siqueira, Jorge Juarez Vieira Teixeira, Rosilene Fressatti Cardoso
• Journal: Microbial drug resistance (Larchmont, N.Y.) (Microb Drug Resist) 2019 Jan/Feb Vol. 25 Issue 1 Pg. 120-126 ISSN: 1931-8448 [Electronic] United States
• PMID: 30096263 (Publication Type: Journal Article, Systematic Review)

Chemical References

• Alkaloids
• Anti-Infective Agents
• Antitubercular Agents
• Benzodioxoles
• Piperidines
• Polyunsaturated Alkamides
• piperine

Topics

• Alkaloids (pharmacology)
• Animals
• Anti-Infective Agents (pharmacology)
• Antitubercular Agents (pharmacology)
• Benzodioxoles (pharmacology)
• Piper (chemistry)
• Piper nigrum (chemistry)
• Piperidines (pharmacology)
• Polyunsaturated Alkamides (pharmacology)
• Tuberculosis (drug therapy)