Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16.

Abstract

The genetic locus for autosomal dominant adult polycystic kidney disease was recently assigned to chromosome 16 by the finding of genetic linkage to the alpha globin gene cluster. Further study showed that the phosphoglycolate phosphatase locus is also closely linked to both the locus for adult polycystic kidney disease and the alpha globin gene cluster. These findings have important implications for the prenatal and presymptomatic diagnosis of adult polycystic kidney disease and for a better understanding of its pathogenesis.

• Authors: S T Reeders, M H Breuning, G Corney, S J Jeremiah, P Meera Khan, K E Davies, D A Hopkinson, P L Pearson, D J Weatherall
• Journal: British medical journal (Clinical research ed.) (Br Med J (Clin Res Ed)) Vol. 292 Issue 6524 Pg. 851-3 (Mar 29 1986) ISSN: 0267-0623 [Print] England
• PMID: 3008903 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Globins
• phosphoglycolate phosphatase
• Phosphoric Monoester Hydrolases

Topics

• Adolescent
• Adult
• Chromosomes, Human, 16-18
• Genetic Linkage
• Globins (genetics)
• Humans
• Pedigree
• Phosphoric Monoester Hydrolases (genetics)
• Polycystic Kidney Diseases (enzymology, genetics)