Effect of warfarin sodium therapy on excretion of 4-carboxy-L-glutamic acid in scleroderma, dermatomyositis, and myositis ossificans progressiva.

The effect of warfarin sodium on excretion of calcium, phosphorus, and 4-carboxy-L-glutamic acid (Gla) was studied in 5 patients with ectopic calcification (2 with scleroderma, 1 with dermatomyositis, and 2 with myositis ossificans progressiva). Warfarin reduced urinary excretion of Gla in all patients, but no changes in calcium and phosphorus excretion or in objective parameters of calcinosis were observed during 6-36 months of treatment. Two patients experienced hemorrhagic complications during therapy, emphasizing a hazard of long-term anticoagulation treatment. Since ectopic calcium deposits contain Gla-rich protein, suppression of Gla synthesis by warfarin sodium over a longer period may prevent deposition and allow removal of existing calcinosis deposits.
AuthorsS E Moore, A A Jump, J D Smiley
JournalArthritis and rheumatism (Arthritis Rheum) Vol. 29 Issue 3 Pg. 344-51 (Mar 1986) ISSN: 0004-3591 [Print] UNITED STATES
PMID3008764 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carbon Radioisotopes
  • Glutamates
  • Phosphorus
  • Warfarin
  • Cyclic AMP
  • Calcium
  • Adult
  • Bone and Bones (radiography, radionuclide imaging)
  • Calcium (urine)
  • Carbon Radioisotopes
  • Chromatography, High Pressure Liquid
  • Cyclic AMP (urine)
  • Dermatomyositis (urine)
  • Female
  • Follow-Up Studies
  • Glutamates (urine)
  • Hemorrhage (chemically induced)
  • Humans
  • Male
  • Middle Aged
  • Myositis Ossificans (urine)
  • Phosphorus (urine)
  • Scleroderma, Systemic (urine)
  • Warfarin (adverse effects, therapeutic use)

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