Thirty-five years of progress in the study of MSH.

Abstract

In this paper, initial work on MSH at Dr. Lerner's laboratory in Portland, Oregon, from 1952 to 1954 is presented. The development of an in vitro bioassay method enabled us to show increased urinary excretion of MSH in Addison's disease. The ability of MSH to increase skin pigmentation in man was also demonstrated. Subsequent work on MSH during the past thirty years is reviewed, such as characterization of alpha- and beta-MSH and their precursors in the pituitary gland and localization of MSH-like peptides in various regions of the brain. Finally there are presented the characterization of gamma-MSH, the hypothermic effect of intracisternal administration of gamma-MSH, the effect of corticortropin releasing factor on increased secretion of alpha-MSH from rat pituitary, and the effect of arginine vasopressin on secretion of alpha-MSH from pituitary adenoma.

• Authors: K Shizume
• Journal: The Yale journal of biology and medicine (Yale J Biol Med) 1985 Nov-Dec Vol. 58 Issue 6 Pg. 561-70 ISSN: 0044-0086 [Print] United States
• PMID: 3008450 (Publication Type: Journal Article)

Chemical References

• Arginine Vasopressin
• Vasoactive Intestinal Peptide
• Adrenocorticotropic Hormone
• Melanocyte-Stimulating Hormones
• Corticotropin-Releasing Hormone

Topics

• Adenoma (metabolism)
• Adrenocorticotropic Hormone (physiology)
• Amino Acid Sequence
• Animals
• Arginine Vasopressin
• Behavior, Animal (drug effects)
• Corticotropin-Releasing Hormone (pharmacology)
• Humans
• Melanocyte-Stimulating Hormones (metabolism, pharmacology, physiology)
• Pituitary Gland (drug effects, metabolism)
• Pituitary Neoplasms (metabolism)
• Rats
• Vasoactive Intestinal Peptide