LAMP1 Overexpression Predicts for Poor Prognosis in Diffuse Large B-cell Lymphoma.

Abstract

INTRODUCTION:

Lysosomal-associated membrane protein 1 (LAMP1) is a lysosomal and plasma membrane protein that contributes to tumor metastatic potential and differentiation.

PATIENTS AND METHODS:

We performed immunohistochemical staining to investigate LAMP1 protein expression levels in 122 diffuse large B-cell lymphoma (DLBCL) tumor samples and 45 reactive hyperplasia tissues. Correlations between LAMP1 expression, various clinicopathologic features, and patient prognosis were evaluated by univariate and multivariate analyses.

RESULTS:

LAMP1 expression was greater in the DLBCL tissues than in the reactive hyperplasia tissues. High LAMP1 expression was significantly associated with a high international prognostic index (score, 3-5; P = .023) and elevated lactate dehydrogenase level (P = .028). Moreover, high LAMP1 expression (P = .026), elevated serum lactate dehydrogenase level (P = .011), and high international prognostic index (P < .001) were independently associated with worse overall survival and progression-free survival.

CONCLUSION:

These data provide the first evidence that LAMP1 expression is associated with a poor prognosis in patients with DLBCL.

• Authors: Qingxiu Dang, Hong Zhou, Juan Qian, Li Yang, Jianfei Huang, Yaping Zhang, Wenyu Shi
• Journal: Clinical lymphoma, myeloma & leukemia (Clin Lymphoma Myeloma Leuk) Vol. 18 Issue 11 Pg. 749-754 (11 2018) ISSN: 2152-2669 [Electronic] United States
• PMID: 30082222 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• LAMP1 protein, human
• Lysosome-Associated Membrane Glycoproteins

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (metabolism)
• Female
• Follow-Up Studies
• Humans
• Lymphoma, Large B-Cell, Diffuse (drug therapy, metabolism, pathology)
• Lysosome-Associated Membrane Glycoproteins (metabolism)
• Male
• Middle Aged
• Prognosis
• Retrospective Studies
• Survival Rate
• Tissue Array Analysis
• Young Adult