Effect of CGS-8216 on high-dose flurazepam convulsive threshold.

Abstract

Flurazepam, a clinically proven and widely accepted sedative hypnotic, has been shown by a number of investigators to produce convulsions at toxic doses. In the present study, CGS-8216, a benzodiazepine receptor antagonist, reduced the dose of flurazepam required to produce convulsions. This suggests that the convulsant action of FLZ is exerted at a site other than the benzodiazepine receptor.

• Authors: W M Bourn, R L Garrett, K M Tolson
• Journal: Pharmacology (Pharmacology) Vol. 32 Issue 3 Pg. 131-3 ( 1986) ISSN: 0031-7012 [Print] Switzerland
• PMID: 3008198 (Publication Type: Journal Article)

Chemical References

• Convulsants
• Pyrazoles
• Receptors, GABA-A
• Benzodiazepines
• 2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one
• Flurazepam

Topics

• Animals
• Benzodiazepines (antagonists & inhibitors)
• Convulsants (pharmacology)
• Dose-Response Relationship, Drug
• Flurazepam (pharmacology)
• Male
• Pyrazoles (pharmacology)
• Rats
• Rats, Inbred Strains
• Receptors, GABA-A (drug effects)