Abstract | OBJECTIVE:: To collect data to estimate the sample size of a definitive randomized controlled trial to evaluate the effects of Melodic Intonation Therapy in post- stroke nonfluent aphasia. DESIGN:: A randomized, crossover, interventional pilot trial. SETTING:: Departments of Neurology and Rehabilitation from a university general hospital. PARTICIPANTS:: INTERVENTIONS:: Patients randomized to group 1 had treatment with Melodic Intonation Therapy first (12 sessions over six weeks) followed by no treatment; the patients in group 2 started active treatment between three and six months after their inclusion in the study, serving as waiting list controls for the first phase. MAIN MEASURES:: The Communicative Activity Log (CAL) questionnaire and the Boston Diagnostic Aphasia Examination (BDAE) were evaluated at baseline, and at six and 12 weeks. RESULTS:: Twenty patients were included. Four of the patients allocated to group 2 crossed over to group 1, receiving the treatment at first. Intention-to-treat analysis: after adjustment for baseline scores, the mean difference in the CAL evaluation from baseline in the treated group was 8.5 points (95% confidence interval (CI), 0.11-17.0; P = .043), with no significant change in any of the BDAE sections. Per-protocol analysis showed similar results with a clear treatment effect ( P = .043) on the CAL. CONCLUSION:: Melodic Intonation Therapy might have a positive effect on the communication skills of stroke survivors with nonfluent aphasia as measured by the CAL questionnaire. A full-scale trial with at least 27 patients per group is necessary to confirm these results.
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Authors | Ana M Haro-Martínez, Genny Lubrini, Rosario Madero-Jarabo, Exuperio Díez-Tejedor, Blanca Fuentes |
Journal | Clinical rehabilitation
(Clin Rehabil)
Vol. 33
Issue 1
Pg. 44-53
(Jan 2019)
ISSN: 1477-0873 [Electronic] England |
PMID | 30056747
(Publication Type: Journal Article, Randomized Controlled Trial)
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Topics |
- Aged
- Aged, 80 and over
- Aphasia, Broca
(etiology, rehabilitation)
- Communication
- Cross-Over Studies
- Female
- Humans
- Male
- Middle Aged
- Pilot Projects
- Speech Therapy
(methods)
- Stroke
(complications)
- Stroke Rehabilitation
(methods)
- Surveys and Questionnaires
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