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[A cooperative phase II study of cisplatin in patients with head and neck cancer].

Abstract
A cooperative phase II study of cisplatin in head and neck cancer was conducted in 23 institutions. Eighty-nine patients were entered into this trial, of which 73 were evaluable. Two different regimens were employed in this study. Regimen A: cisplatin 10 mg/m2 intravenous (i.v.) infusion daily, days 1-5, q 3 wk. Regimen B: cisplatin 50 mg/m2 i.v. infusion, day 1, q 3 wk. Two patients achieved complete response and 17 achieved partial response with an overall response rate of 26.0%. By histological types, the response rate was 26.3% in the case of squamous cell carcinoma. Partial response were observed in 2 cases of adenocarcinoma and in one case each of adenoid cystic carcinoma and transitional cell carcinoma. The response rate was 19.4% for previously treated patients, as compared to 63.6% for the previously untreated group. Toxic effects were observed in 94.7% of 76 evaluable cases. From 50 to 68% of patients experienced nausea, vomiting and anorexia. No patient exhibited a serum creatinine level exceeding 2 mg/dl. Anemia and leukopenia were observed in 58.9% and 32.9% respectively. It is therefore concluded that cisplatin is markedly useful for the treatment of head and neck cancer.
AuthorsY Inuyama, C Takeda
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 13 Issue 2 Pg. 232-8 (Feb 1986) ISSN: 0385-0684 [Print] Japan
PMID3004363 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cisplatin
Topics
  • Adenocarcinoma (drug therapy)
  • Adult
  • Aged
  • Carcinoma, Adenoid Cystic (drug therapy)
  • Carcinoma, Squamous Cell (drug therapy)
  • Cisplatin (administration & dosage, therapeutic use)
  • Drug Administration Schedule
  • Drug Evaluation
  • Female
  • Head and Neck Neoplasms (drug therapy)
  • Humans
  • Infusions, Parenteral
  • Male
  • Middle Aged
  • Mouth Neoplasms (drug therapy)
  • Nose Neoplasms (drug therapy)
  • Paranasal Sinus Neoplasms (drug therapy)

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