[Criteria for the selection of drugs for the pathogenetic treatment of Itsenko-Cushing disease].

Abstract

The authors presented the results of a study of the level of corticotropin and cortisol in the blood at different time after a single intake of peritol or parlodel in 48 patients with Icenko-Cushing disease at the active stage. Corticotropin and cortisol concentrations were determined by radioimmunoassay with the help of standard kits. The study showed a different sensitivity of patients with Icenko-Cushing disease to peritol and parlodel. According to the expression of the reaction of the hypophyseal-adrenal system all the patients were divided into the following groups: with a noticeable reaction to one or both drugs, with a slightly noticeable decrease in the level of hormones or a paradoxical reaction to the drugs. A single test with inhibitors of hypophyseal corticotropic function provided an opportunity for an individual choice of an effective drug for pathogenetic treatment of patients with Icenko-Cushing disease. The optimum time for blood examination to determine the concentration of corticotropin was 1 and 2 hrs, the level of cortisol 2-4 hrs after the intake of peritol and parlodel.

• Authors: V N Slavnov, E V Luchitskiĭ, A K Cheban
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 57 Issue 12 Pg. 36-9 ( 1985) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Kriterii vybora preparata dlia patogeneticheskogo lecheniia bolezni Itsenko-Kushinga.
• PMID: 3003946 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Cyproheptadine
• Bromocriptine
• Adrenocorticotropic Hormone
• Hydrocortisone

Topics

• Adrenocorticotropic Hormone (metabolism)
• Adult
• Bromocriptine (therapeutic use)
• Clinical Trials as Topic
• Cushing Syndrome (drug therapy, etiology)
• Cyproheptadine (therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Hydrocortisone (metabolism)
• Male
• Middle Aged
• Pituitary-Adrenal System (metabolism)