Abstract | OBJECTIVES: Determine ancillary test utilization for the workup of isolated eosinophilia in otherwise morphologically unremarkable bone marrow (BM). METHODS: We evaluated BM ancillary testing performed in cases with isolated eosinophilia and otherwise morphologically unremarkable BM. Cases with abnormal morphology (eg, dysplasia, basophilia) and/or findings suggestive of a disorder (eg, unexplained thromboses, lymphoma) are specifically excluded. RESULTS: CONCLUSIONS: Findings from our institutional experience support initial testing in isolated eosinophilia with otherwise unremarkable BM to include PDGFRA rearrangement, tryptase/CD25 immunohistochemistry, cytogenetics, and T-cell flow cytometry/receptor gene rearrangement. This approach achieves diagnostic quality and test utilization efficiency in our clinical practice.
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Authors | Hong Fang, Rhett P Ketterling, Curtis A Hanson, Animesh Pardanani, Paul J Kurtin, Dong Chen, Patricia T Greipp, Matthew T Howard, Rebecca L King, Daniel L Van Dyke, Kaaren K Reichard |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 150
Issue 5
Pg. 421-431
(Oct 01 2018)
ISSN: 1943-7722 [Electronic] England |
PMID | 30032299
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- IL2RA protein, human
- Interleukin-2 Receptor alpha Subunit
- PDGFRB protein, human
- Receptor, Platelet-Derived Growth Factor beta
- Tryptases
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Algorithms
- Bone Marrow
(pathology)
- Child
- Cohort Studies
- Eosinophilia
(pathology)
- Female
- Gene Rearrangement
- Humans
- Hypereosinophilic Syndrome
(diagnosis, genetics, pathology)
- Interleukin-2 Receptor alpha Subunit
(metabolism)
- Leukemia
(diagnosis, genetics, pathology)
- Male
- Mastocytosis, Systemic
(diagnosis, genetics, pathology)
- Middle Aged
- Mutation
- Receptor, Platelet-Derived Growth Factor beta
(genetics)
- Retrospective Studies
- Tryptases
(metabolism)
- Young Adult
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