[Delayed neurotoxic action of a new fungicide aphos].

Abstract

It has been established that administration of aphos to chickens within a wide dose range (3000-25 mg/kg) produces a retarded neurotoxic action that is manifested by the development of ataxia, pareses and paralyses; delay in the rate of the distribution of excitation via the peripheral axons, disorders of myoneural lability; degeneration of myelin fibers, focal granular degradation of myelin. The retarded neurotoxic action is not caused by impurities contained by the technical-grade preparation in view of the fact that such an action is also common to the chemically pure aphos.

• Authors: I I Tkachenko, Iu S Kagan, N V Kokshareva, L N Badaeva
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1985 Nov-Dec Vol. 48 Issue 6 Pg. 80-3 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Zamedlennoe neĭrotoksicheskoe deĭstvie novogo fungitsida afosa.
• PMID: 3002846 (Publication Type: English Abstract, Journal Article)

Chemical References

• Emulsions
• Fungicides, Industrial
• Organophosphorus Compounds
• aphos

Topics

• Action Potentials (drug effects)
• Animals
• Chickens
• Dose-Response Relationship, Drug
• Drug Contamination
• Emulsions
• Female
• Fungicides, Industrial (poisoning, toxicity)
• Neuromuscular Junction (drug effects, physiology)
• Organophosphate Poisoning
• Organophosphorus Compounds (toxicity)
• Peripheral Nerves (drug effects)
• Peripheral Nervous System Diseases (chemically induced)
• Synaptic Transmission (drug effects)
• Time Factors