[Effect of phenobarbital on the kinetics of the change in the level of paramagnetic metalloprotein complexes in dinitrophenol poisoning].

Abstract

EPR spectroscopy was used to study phenobarbital influence on the kinetics of paramagnetic complexes variability of metal proteins--cytochrome P-450 and iron-sulfur proteins of rat liver in acute oral poisoning with the dinitrophenol pesticides DNOK and dinoseb. It was proved experimentally that the barbiturate favoured marked prevention of the decrease of the content of cytochrome P-450 and iron-sulfur proteins, thereby protecting the detoxifying and energy liver system from dinitrophenol-induced injuries. It is discussed that phenobarbital may act both as an inducer of cytochrome P-450 and iron-sulfur proteins involved in electron transport of the mitochondria.

• Authors: V D Luk'ianchuk
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1985 Nov-Dec Vol. 48 Issue 6 Pg. 102-4 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie fenobarbitala na kinetiku izmeneniia urovnia paramagnitnykh kompleksov nekotorykh metalloproteidov pri intoksikatsii dinitrofenolami.
• PMID: 3002843 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antidotes
• Dinitrophenols
• Metalloproteins
• Phenobarbital

Topics

• Acute Disease
• Animals
• Antidotes
• Dinitrophenols (poisoning)
• Drug Evaluation, Preclinical
• Electron Spin Resonance Spectroscopy
• Kinetics
• Liver (analysis, drug effects, metabolism)
• Male
• Metalloproteins (analysis, metabolism)
• Phenobarbital (therapeutic use)
• Rats
• Rats, Inbred Strains
• Time Factors