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Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine.

Abstract
Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. Of the 14 eyes with retinitis, eight demonstrated more than 90% resolution, four had partial improvement, one failed to respond, and one could not be evaluated. Two of the eight patients had chemotherapy-induced immunosuppression and had ocular remissions for at least several months. The remaining six patients had AIDS or probable AIDS and relapsed in five weeks or less after discontinuation of therapy. Dihydroxy propoxymethyl guanine appears to be effective biologically in treating human cytomegalovirus retinitis without the development of unacceptable side effects but a single course of therapy is not capable of eradicating the virus.
AuthorsA G Palestine, G Stevens Jr, H C Lane, H Masur, L S Fujikawa, R B Nussenblatt, A H Rook, J Manischewitz, B Baird, M Megill
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 101 Issue 1 Pg. 95-101 (Jan 15 1986) ISSN: 0002-9394 [Print] United States
PMID3002177 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Ganciclovir
  • Acyclovir
Topics
  • Acquired Immunodeficiency Syndrome (complications)
  • Acyclovir (analogs & derivatives, therapeutic use)
  • Adult
  • Cytomegalovirus Infections
  • Drug Evaluation
  • Female
  • Ganciclovir
  • Humans
  • Male
  • Middle Aged
  • Recurrence
  • Retinitis (complications, drug therapy, etiology, pathology)
  • Visual Acuity

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