Immunotoxicity of aflatoxin M1 : as a potent suppressor of innate and acquired immune systems in a subacute study.

Abstract

BACKGROUND:

Although, to date, there have been several in vitro and in vivo studies of immunomodulatory effects of aflatoxin M1 (AFB1 ), little is known about the effect of AFM1 on various aspects of innate and acquired immunity. In the present study, AFM1 was administered intraperitoneally, at doses of 25 and 50 μg kg-1 , body mass for 28 days and various immunological parameters were measured.

RESULTS:

Several parameters related to immune function were suppressed: organ mass, cellularity of spleen, proliferation response to lipopolysaccaride and phytohemagglutinin-A, hemagglutination titer, delayed type of hypersensitivity response, spleen cell subtypes, serum hemolytic activity, serum immunoglobulin G level and cytokine production. AFM1 did not cause changes in body mass, hematological parameters or the concentration of immunoglobulin M in blood serum.

CONCLUSIONS:

Overall, the data suggested that AFM1 suppressed innate and acquired immunity. Therefore, with respect to consumer safety, it is extremely important to further control the level of AFM1 in milk, and this should be considered as a precedence for risk management actions. © 2018 Society of Chemical Industry.

• Authors: Kobra Shirani, Bamdad R Zanjani, Mahmoud Mahmoudi, Amir H Jafarian, Faezeh V Hassani, John P Giesy, Gholamreza Karimi
• Journal: Journal of the science of food and agriculture (J Sci Food Agric) Vol. 98 Issue 15 Pg. 5884-5892 (Dec 2018) ISSN: 1097-0010 [Electronic] England
• PMID: 30014474 (Publication Type: Journal Article)
• Copyright: © 2018 Society of Chemical Industry.

Chemical References

• Cytokines
• Aflatoxin M1

Topics

• Adaptive Immunity (drug effects)
• Aflatoxin M1 (administration & dosage, toxicity)
• Animal Feed
• Animals
• Cell Proliferation (drug effects)
• Cytokines (genetics, immunology)
• Humans
• Hypersensitivity, Delayed (etiology, genetics, immunology)
• Immunity, Innate (drug effects)
• Lymphocytes (cytology, drug effects)
• Male
• Mice
• Mice, Inbred BALB C
• Spleen (drug effects, immunology)