[Ophthalmic use of clindamycin-2-phosphate (author's transl)].

Abstract

Bacterial and clinical experiments for ophthalmic use of clindamycin-2-phosphate (CLDM-2-P) were performed and the results were summarized as follows. 1. The distribution of sensitivity for 100 strains of Staphylococcus aureus isolated in 1975 was in the range of less than or equal to 0.19 approximately greater than or equal to 100 mug/ml, and majority of them (96.0%) were in less than or equal to 0.39 mug/ml. 2. The serum concentration by intramuscular injection of 300 mg and 600 mg CLDM-2-P in a single dose respecitvely reached the peak level after 2 hours and decreased gradually until 12 hours in both of them. 3. Ocular penetrations were examined in rabbit eyes. (1) After instillation of 1% CLDM-2-P solution, the aqueous level reached the highest after 1 hour and measurable after 6 hours. (2) After subconjunctival injection of 5 mg/0.5 ml CLDM-2-P, the aqueous level reached the highest after 2 hours and decreased until 6 hours. (3) After intramuscular injection of 100 mg/kg, the aqueous concentration was recognized from 1 to 8 hours, and peak was reached after 1 hour. 1 to 8 hours, and peak was reached after 1 hour. Aqueous-serum ratio in 1 hour was 37.13%. The ocular tissue concentrations at 2 hours showed relatively high levels in both of outer and inner parts of the eye. 4. The intramuscular injection of CLDM-2-P, 300 approximately 1800 mg daily, against suppurative ocular infections revealed excellent effects on cases of external hordeolum, acute chalazion, lid abscess, orbital phlegmone, corneal infiltration, corneal ulcer, and iridocyclitis purulenta. 5. Side effects: Two cases out of 22 cases complained of diarrhoea and bitter taste after injection, and able to be treated continuously by the drug. No abnormal findings in hepatic and renal tests were observed and no servere side effects like allergic reactions were recognized.

• Authors: M Oishi, K Nishizuka, M Motoyama, T Ogawa
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 30 Issue 1 Pg. 100-6 (Jan 1977) ISSN: 0368-2781 [Print] Japan
• PMID: 300120 (Publication Type: English Abstract, Journal Article)

Chemical References

• Organophosphorus Compounds
• Clindamycin

Topics

• Abscess (drug therapy)
• Acute Disease
• Adult
• Aged
• Animals
• Cellulitis (drug therapy)
• Clindamycin (analogs & derivatives, metabolism, therapeutic use)
• Corneal Diseases (drug therapy)
• Corneal Ulcer (drug therapy)
• Dacryocystitis (drug therapy)
• Drug Resistance, Microbial
• Endophthalmitis (drug therapy)
• Eye (metabolism)
• Eye Diseases (drug therapy)
• Eyelid Diseases (drug therapy)
• Female
• Hordeolum (drug therapy)
• Humans
• Male
• Meibomian Glands
• Middle Aged
• Orbit
• Organophosphorus Compounds
• Rabbits
• Staphylococcus aureus (drug effects)
• Uveitis, Anterior (drug therapy)