Comparison of passive and scanning irradiation methods for carbon-ion radiotherapy for breast cancer.

Abstract

The dose distribution of passive and scanning irradiation for carbon-ion radiotherapy for breast cancer was compared in order to determine the preferred treatment method. Eleven Japanese patients who received carbon-ion radiotherapy for breast cancer were retrospectively analyzed. The original clinical plans were used for the passive irradiation method, while the plans for the scanning irradiation method were more recently made. Statistical analysis suggested that there was no significant difference in superiority in terms of dose distribution between the passive and scanning irradiation methods. The present study found that the scanning irradiation method was not always superior to the passive method, despite a previous study having reported the superiority of scanning irradiation. The present result is considered to arise from characteristics of breast cancer treatment, such as the simplicity of the organ at risk and the shallow depth point of the target from the skin. It is noteworthy that the present study suggests that the passive irradiation method can provide better dose distribution, depending on the case.

• Authors: Hiroaki Matsubara, Kumiko Karasawa, Wataru Furuichi, Mitsuji Wakaisami, Shintaro Shiba, Masaru Wakatsuki, Tokuhiko Omatsu, Taku Inaniwa, Shigekazu Fukuda, Tadashi Kamada
• Journal: Journal of radiation research (J Radiat Res) Vol. 59 Issue 5 Pg. 625-631 (Sep 01 2018) ISSN: 1349-9157 [Electronic] England
• PMID: 30010816 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Carbon

Topics

• Aged
• Aged, 80 and over
• Breast Neoplasms (radiotherapy)
• Carbon (therapeutic use)
• Female
• Heavy Ion Radiotherapy (methods)
• Humans
• Japan
• Middle Aged
• Organs at Risk
• Radionuclide Imaging
• Radiotherapy Dosage
• Radiotherapy Planning, Computer-Assisted (methods)
• Radiotherapy, Conformal (methods)
• Retrospective Studies