Predictive value of diffusion-weighted MR imaging in early response to chemoradiotherapy of esophageal cancer: a meta-analysis.

Abstract

The results of diffusion-weighted MR imaging (DW-MRI) in predicting early response to chemoradiotherapy in patients with esophageal cancer varied in different studies. We performed this meta-analysis to evaluate the predictive values of DW-MRI and compare the diagnostic efficacy of different apparent diffusion coefficients (ADCs). A comprehensive literature search was performed to identify relevant articles published before November 2017. The quality of study was assessed using Quality Assessment of Diagnostic Accuracy Studies-2. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under receiver operating characteristic curve of ADC values were calculated to determine the diagnostic performance. Seven studies with a total of 236 patients were included. The pooled sensitivity, specificity, DOR, and area under curve were 93% (95% CI 77%-98%), 85% (95% CI 72%-93%), 78 (95% CI 15-401), and 0.91 (95% CI 0.89-0.94), respectively, for the ▵ADC; and 75% (95% CI 62%-84%), 90% (95% CI 67%-97%), 26 (95% CI 6-110), and 0.85 (95% CI 0.82-0.88), respectively, for the post-ADC. For pre-ADC, meta-analysis was not performed because of conflicting results. In conclusions, our results demonstrate that DW-MRI has good performance for evaluating the response to chemoradiation therapy in patients with esophageal cancer. ▵ADC and post-ADC are promising reliable and valuable predictors.

• Authors: B Cheng, J Yu
• Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus (Dis Esophagus) Vol. 32 Issue 4 (Apr 01 2019) ISSN: 1442-2050 [Electronic] United States
• PMID: 30010733 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © The Author(s) 2018. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus.

Topics

• Adult
• Aged
• Chemoradiotherapy (statistics & numerical data)
• Diffusion Magnetic Resonance Imaging (statistics & numerical data)
• Esophageal Neoplasms (diagnostic imaging, therapy)
• Female
• Humans
• Male
• Middle Aged
• Odds Ratio
• Predictive Value of Tests
• ROC Curve
• Sensitivity and Specificity
• Treatment Outcome