Abstract |
The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.
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Authors | R T Johnson, D S Burke, M Elwell, C J Leake, A Nisalak, C H Hoke, W Lorsomrudee |
Journal | Annals of neurology
(Ann Neurol)
Vol. 18
Issue 5
Pg. 567-73
(Nov 1985)
ISSN: 0364-5134 [Print] United States |
PMID | 3000282
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Viral
- Antigens, Viral
- Immunoglobulin G
- Immunoglobulin M
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Topics |
- Antibodies, Viral
(cerebrospinal fluid)
- Antigens, Viral
(immunology)
- B-Lymphocytes
(immunology)
- Brain
(immunology, pathology)
- Child
- Child, Preschool
- Encephalitis Virus, Japanese
(immunology)
- Encephalitis, Japanese
(immunology, pathology)
- Humans
- Immunoenzyme Techniques
- Immunoglobulin G
(cerebrospinal fluid)
- Immunoglobulin M
(cerebrospinal fluid)
- Infant
- Macrophages
(immunology)
- Phagocytosis
- T-Lymphocytes
(immunology)
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