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Japanese encephalitis: immunocytochemical studies of viral antigen and inflammatory cells in fatal cases.

Abstract
The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.
AuthorsR T Johnson, D S Burke, M Elwell, C J Leake, A Nisalak, C H Hoke, W Lorsomrudee
JournalAnnals of neurology (Ann Neurol) Vol. 18 Issue 5 Pg. 567-73 (Nov 1985) ISSN: 0364-5134 [Print] United States
PMID3000282 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Viral
  • Antigens, Viral
  • Immunoglobulin G
  • Immunoglobulin M
Topics
  • Antibodies, Viral (cerebrospinal fluid)
  • Antigens, Viral (immunology)
  • B-Lymphocytes (immunology)
  • Brain (immunology, pathology)
  • Child
  • Child, Preschool
  • Encephalitis Virus, Japanese (immunology)
  • Encephalitis, Japanese (immunology, pathology)
  • Humans
  • Immunoenzyme Techniques
  • Immunoglobulin G (cerebrospinal fluid)
  • Immunoglobulin M (cerebrospinal fluid)
  • Infant
  • Macrophages (immunology)
  • Phagocytosis
  • T-Lymphocytes (immunology)

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